Peripheral arterial disease (PAD) in the legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can happen in any blood vessel, but it is more common in the legs than the arms.
The following investigator-initiated study has been launched at the Department of Angiology and is sponsored by the University of Zurich:
The Department of Angiology is involved in the design and conduction of the following multinational studies:
XATOA phase IV trial (NCT03746275): Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid. The study enrolled adult patients suffering from coronary artery disease or peripheral artery disease, and treated with rivaroxaban 2.5 mg twice daily (Xarelto vascular) in addition to aspirin. Sponsor: Bayer. Status: recruitment completed.
Wolf S, Spirk D, Forgo G, Sebastian T, Voci D, Kucher N, Barco S. Prevalent use of high-intensity statin therapy and LDL-C target attainment among PAD patients undergoing angioplasty. Vasa 2022. 10.1024/0301-1526/a001025.
Barco S, Sebastian T, Voci D, Engelberger RP, Grigorean A, Holy E, Leeger C, Münger M, Périard D, Probst E, Spescha R, Held U, Kucher N. Major adverse limb events in patients with femoro-popliteal and below-the-knee peripheral arterial disease treated with either sirolimus-coated balloon or standard uncoated balloon angioplasty: a structured protocol summary of the “SirPAD” randomized controlled trial. Trials 2022 Apr 21;23(1):334.