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Rare Vascular Diseases

  • RAVE-T study (2021-02262): Clinical presentation, treatment pattern and course of RAre VEnous Thrombosis and Thromboembolism. This study is conducted as a retrospective analysis of medical charts of patients with rare venous thromboses (such as plantar vein thrombosis, thrombosis of the ovarian vein, renal vein, mesenterial vein etc.) diagnosed and followed at the University Hospital Zurich. The primary objective of this retrospective study is to describe practice-based, real-world data on the characteristics of clinical presentation, treatment pattern and course among patients with rare venous thromboses treated at the University Hospital Zurich over the past decade. Sponsor: University of Zurich. Status: ongoing.
  • BATTLE registry: Bacteria-Associated Thrombosis/Thrombophlebitis and LEmierre syndrome. BATTLE is an ambispective, disease-specific, non-population based, multicentre clinical registry of global reach and multidisciplinary scope, specifically designed to address the limitations of current evidence and to provide patients and physicians with clinically viable information to guide management and improve the outcomes of those affected by Lemierre syndrome and other forms of bacterial thrombophlebitis. Sponsor: University of Mainz. Status: approval pending.
  • Transient perivascular inflammation of the carotid artery (TIPIC) syndrome: An updated multinational analysis. The Transient Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is characterized by a local transient inflammation of the tissue around the carotid artery. Its pathophysiology remains unknown. We performed an updated study of TIPIC syndrome cases in the setting of a multinational collaborative study. Status: published.
  • Clinical presentation and long-term follow-up of patients with Mondor disease (2020-00292). Status: published.

Valentin ML*, Barco S, Studer G, Clemens RK, Kreuzpointner R, Sebastian T, Thalammer C, Kucher N. Prevalence of carotid plaque stenosis after head and neck radiotherapy. A prospective cohort study of 156 survivors. Vasa 2020; 49(6):467-473.

Barco S, Sollfrank S, Trinchero A, Adenaeuer A, Abolghasemi H, Conti L, Häuser F, Kremer Hovinga JA, Lackner KJ, Loewecke F, Miloni E, Shiran NV, Tomao L, Wuillemin WA, Zieger B, Lämmle B, Rossmann H. Severe plasma prekallikrein deficiency: Clinical characteristics, novel KLKB1 mutations, and estimated prevalence. J Thromb Haemost 2020; 18(7):1598-1617.

Valerio L, Zane F, Sacco C, Granziera S, Nicoletti T, Russo M, Corsi G, Holm K, Righini C, Karkos PD, Mahmoudpour SH, Kucher N, Verhamme P, Di Nisio M, Centor RM, Konstantinides SV, Pecci A, Barco S. Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. Journal Internal Medicine 2020; 289(3):325-339.

Micieli E, Voci D, Mumoli N, Mastroiacovo D, Grigorean A, Obadia M, de Champfleur NM, Naggara O, Carsin B, Amor-Sahli M, Cottier JP, Bensoussan J, Auffray-Calvier E, Varoquaux A, Bonneville F, Sadik JC, Kucher N, Lecler A, Barco S*. Transient perivascular inflammation of the carotid artery (TIPIC) syndrome. Vasa 2022 Feb 8. doi: 10.1024/0301-1526/a000989.

Kreuzpointner R, Johner F, Roth-Zetzsche S, Kucher N, Barco S*. Clinical presentation and long-term follow-up of 45 patients with Mondor disease: A single-center longitudinal study. Vascular med 2021; 1358863X211000420.