ADP-ribosylation, inflammation, mass spectrometry, NF-kappaB
We investigatethe molecular mechanisms ofinflammation-associated diseases (i.e.cancer) with a special focus on signalling eventsin cancersthat are regulated byprotein ADP-ribosylation. We aimbased on this detailed knowledge to lay the foundation for novel diagnostic and therapeutic approaches.
My laboratory has a long-standing interest in understanding molecular mechanisms of inflammation-associated diseases of which cancer is a major topic. We investigate the role of post-translations modifications (PTM), particularly ADP-ribosylation,in the regulation of cancer developmentand progressionand found that ADP-ribosylation as a crucial process in the cellular response to detrimental stimuli, be it through genotoxicity, oxidative or metabolic stress. Furthermore, we investigate the involved key enzymes, such as writers, readers and eraser of ADP-ribosylation, as well as their target proteins that carry this PTM. We focuson the following questions:
We have been involved in several breakthrough discoveries such as the mass spectrometry-based identification of the ADP-ribosylome (modified proteins and their acceptor sites) in cells and tissues, as well as the generation of antibodies that recognize ADP-ribosylated peptides and reveal tumor tissue-specific ADP-ribosylation.Publications