Philipp Dutkowski
Prof. Dr. med.

Das Wichtigste in Kürze

Professor Dutkowski ist ein international bekannter Chirurg, der in Deutschland ausgebildet wurde und 2004 von der Universitätsklinik Mainz nach Zürich wechselte. Unter seiner Führung vergrösserte sich die Zahl der Lebertransplantationen am USZ erheblich, bei exzellenten Ergebnissen. Es wurden hochspezialisierte Programme wie die Lebend-Lebertransplantation für Krebs der Gallenwege entwickelt. Prof. Dutkowski verstärkt das HPB-Team neben der Leitung des Transplantationsteams.

Key skills

• Transplantation Surgery
• Hepato-pancreatico-biliary Surgery
• Abdominal Surgery
• Oncological Surgery

Background

• 2011 Titularprofessur University of Zurich
• 2009 Umhabilitation University of Zurich
• Since 2009 Consultant, Head of Abdominal Organ Transplantation
• 2004-2009 Staff Surgeon, Department of Surgery & Transplantation, University Hospital Zurich
• 1999-2004 Staff Surgeon, Department of General and Abdominal Surgery, University of Mainz
• 2002 Board Qualification Visceral Surgery
• 2001 Habilitation University of Mainz
• 1999 Board Qualification General Surgery

Publications

• H factor 47, 7284 citations (Google scholar)
• 165 peer reviewed publications
• 16 book chapters

Key Original Papers first/ senior author, (n=10, mean impact factor 16)

• Muller X, Schlegel A, Kron P, Eshmuminov D, Würdinger M, Meierhofer D, Clavien PA, Dutkowski P. Novel real time prediction of liver graft function during hypothermic oxygenated machine perfusion before liver transplantation
  Ann Surg 2019, 270, 783-790.
• Schlegel A, Muller X, Kalisvaart M, Müllhaupt B, Perera MTPR, Isaac J, Clavien PA, Muiesan P, Dutkowski P. Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation.
  J Hepatol 2019, 70: 50-57
• Kron P*, Schlegel A*, Mancina L, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion for fatty liver grafts in rats and humans
  J Hepatol 2017 Sep 1. pii: S0168-8278(17)32268-7.
• Kron P*, Schlegel A*, De Rougemont O, Oberkofler CE, Clavien P.A, Dutkowski P. Short, cool and well oxygenated – HOPE for Kidney Transplantation in a Rodent Model
  Ann Surg 2016 Nov; 264(5):815-822.
• Dutkowski P,*, Polak W*, Muiesan P*, Schlegel A, Verhoeven C, Scalera I, De Oliveira M, Kron P, Clavien PA. First Comparison of hypothermic oxygenated perfusion (HOPE) vs static cold storage of human DCD liver transplants. An international matched case analysis.
  Ann Surg 2015, 262:764-770.
• Schlegel A, Kron P, Graf R, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation.
  Ann Surg 2014, 260: 931-937.
• Schlegel A, Kron P, Graf R, Dutkowski P, and Clavien PA*. Warm vs. cold machine perfusion to rescue liver grafts in a rodent model of liver transplantation.
  J Hepatol 2014, 61: 1267-1275.
• Dutkowski P, Schlegel A*, de Oliveira M, Müllhaupt B, Neff F, Clavien PA. HOPE for human liver grafts obtained after cardiac death.
  J Hepatol 2014, 60: 765-772.
• Schlegel A, Graf R, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) protects from biliary injury in a rodent model of DCD liver transplantation
  J Hepatol 2013, 59: 984-991.
• Schlegel A, de Rougemont O, Graf R, Clavien PA, Dutkowski P. Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts.
  J Hepatol 2013, 58: 278-286.

Memberships

• Deutsche Gesellschaft für Chirurgie (DGC)
• Swiss Transplant Society (STS)
• International Liver Transplant Society (ILTS)
• European Society for Organ Transplantation (ESOT)
• European Association for the Study of the Liver (EASL)
• European African Hepato-Pancreatico-Biliary Association (EAHPBA)
• International Hepato-Pancreatico-BiliaryAssociation (IHPBA)
• European Surgical Association (ESA)

Key areas of research

• Liver transplantation
• Kidney transplantation
• Ischemia/reperfusion injury
• Machine liver/kidney perfusion
• Prediction of organ function before implantation
• Allocation models for organs
• Individual immuno suppression after transplantation

Grants

• 1995
  German Research Society (DFG) stipendiat (Research residency at the University of Wisconsin, Department of Surgery, Organ preservation laboratory, Prof. J.H.  Southard)
• 2004
  Novartis Stiftung for Medical Research : “Hypothermic oxygenated perfusion of the cold stored rat liver in non-heart beating donors”.
• 2007
  SNF grant 3200B0-118090 (Principal Investigator): Hypothermic oxygenated perfusion (HOPE) of non heart beating donor livers prior to transplantation
• 2009
  SNF grant 32002B-135591 (Co-Investigator) : Sevoflurane in liver transplantation
• 2012
  SNF grant 32003B-140776/1(Principal Investigator): Machine perfusion of DCD livers for protection from biliary injury
• 2014
  SNF grant 32003B-15312 (Principal Investigator): HOPE for human liver grafts obtained from donors after brain death
• 2015
  Innovation grant University Hospital Zurich: HOPE for human extended criteria liver grafts
• 2016
  SNF grant 33IC30_166909/1 (Principal Investigator) Investigator Initiated clinical trial: HOPE for human livers- a prospective randomized European liver transplant trial
• 2020
  SNF grant 320030_189055 (Principal Investigator) Assessment of liver function during machine perfusion before transplantation