Research group Karin Metzner

HIV-1 genomics in vivo

We are interested in the genomic organisation, diversity and evolution of HIV-1 and their consequences on pathogenesis, drug resistance, latency, and transmission.

Our current research projects comprise investigations on (1) the evolution of HIV-1 and the mechanisms of viral escape from the selective pressure of antiretroviral drugs (2) identifying factors underlying latency and the impact of HIV-1 integration sites on pathogenesis, and (3) the development of gene therapy approaches to combat HIV-1.