High-resolution esophageal manometry (HRM)

Esophageal manometry is the gold standard for confirming the diagnosis of achalasia. The lack of esophageal peristalsis by definition and the lack of relaxation of the lower esophageal sphincter can be demonstrated here.

An increased resting pressure (> 45 mm Hg) in the lower sphincter can also be detected in approx. 50% of patients. Based on the manometric findings, 3 subtypes of achalasia are differentiated according to the Chicago Classification (see general information). This distinction is now important for the therapeutic approach.

During esophageal manometry, a thin catheter with multiple pressure measuring probes (high-resolution esophageal manometry, HRM) is inserted through the nose of the awake patient after anesthetizing the nose with a gel. The patient can drink some water with a straw, which makes the insertion much easier due to the natural peristalsis. The examination is harmless and is tolerated by >90% of patients.

The test protocol is firmly defined and includes single sips, free rapid drinking of water (MRS – mutliple rapid swallows) and a test meal of cooked rice. The measured pressure curves are then assessed by experienced examiners.

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University Hospital Zurich
Department of Gastroenterology and Hepatology
Raemistrasse 100
8091 Zurich

Tel. +41 44 255 85 48
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