Chronic venous insufficiency (CVI) is a condition that occurs when the venous wall and/or valves in the veins are not working effectively, making it difficult for blood to return to the heart from the legs.
CVI may occur after an episode of deep vein thrombosis: in this case, it is denominated “post-thrombotic syndrome” (PTS). A combination of reflux due to incompetence of the venous valves and venous hypertension due to thrombotic obstruction is thought to underlie the pathophysiology of post-thrombotic syndrome.
Pelvic congestion syndrome (PCS) is a medical condition that causes chronic pelvic pain. The condition is thought to be due to problems with the enlarged or incompetent veins in the pelvic area and it is considered a form of CVI.
The following investigator-initiated studies have been launched at the Department of Angiology and are sponsored by the University of Zurich:
The Department of Angiology is involved in the design and conduction of the following multinational studies:
Neuenschwander J, Sebastian T, Barco S, Spirk D, Kucher N. A novel management strategy for treatment of pelvic venous disorders utilizing a clinical screening score and non-invasive imaging. Vasa 2022;51(3):182-189.
Sebastian T, Barco S, Lichtenberg M, Stahlhoff S, Schlager O, Jalaie H, de Graaf R, Erbel C, Massmann A, Schindewolf M, Kucher N. Twelve-month clinical outcomes of a hybrid oblique self-expanding nitinol stent used for the treatment of post-thrombotic syndrome with common iliac vein compression: The TOPOS study. Vasc Med 2021;26(5):569-571.
Sebastian T, Barco S, Kreuzpointner R, Konstantinides S, Kucher N. Reversal of cardiopulmonary exercise intolerance in patients with post-thrombotic obstruction of the inferior vena cava. Thromb Res 2021;208:219-225
Sebastian T, Spirk D, Engelberger RP, Dopheide, JF, Baumann, FA, Barco S, Spescha R, Leeger C, Kucher N. Incidence of Stent Thrombosis after Endovascular Treatment of Iliofemoral or Caval Veins in Patients with the Postthrombotic Syndrome. Thromb Haemost 2019; 119(12):2064-2073.
Sebastian T, Barco S, Engelberger RP, Spirk D, Schindewolf M, Spescha R, Baumann F, Baumgartner I, Kucher N*. Duplex sonography for the detection of obstructed iliocaval venous stents. Eur J Vasc Endovasc Surg 2020; 60(3):443-450.
Sebastian T, Gnanapiragasam S, Spirk D, Engelberger RP, Moeri L, Lodigiani C, Kreuzpointner R, Barco S, Kucher N*. Self-Expandable Nitinol Stents for the Treatment of Nonmalignant Deep Venous Obstruction. Circulation: Cardiovascular Interventions 2020 13(12):e009673.
Moeri L, Lichtenberg M, Gnanapiragasam S, Barco S, Sebastian T*. Braided or laser-cut self-expanding nitinol stents for the common femoral vein in patients with the post-thrombotic syndrome. J Vasc Surg Venous Lymphat Disord 2020; S2213-333X(20)30465-0.