The research unit of the Department of Angiology has the goal of establishing novel pharmacological and interventional strategies for the management of acute venous thromboembolism.
Venous thromboembolism (VTE), clinically presenting as deep vein thrombosis (DVT) or acute pulmonary embolism (PE), is the third most frequent acute cardiovascular syndrome after myocardial infarction and stroke. The research unit of the Department of Angiology has the goal of establishing novel pharmacological and interventional strategies for the management of acute venous thromboembolism. Our research includes multinational randomized clinical trials, prospective management studies, epidemiological analyses, and observational practice-based studies.
Professor Nils Kucher and PD Dr. Stefano Barco serve as experts and panellists for international guidelines and consensus documents on the treatment of venous thromboembolism.
The following investigator-initiated trials studies have been launched at the Department of Angiology and are sponsored by the University of Zurich:
The Department of Angiology is involved in the design and conduction of the following multinational trials and observational studies:
Voci D, Zbinden S, Micieli E, Kucher N, Barco S. Fixed-Dose Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Pulmonary Embolism Associated with COVID-19. Viruses 2022;14(8):1606.
Barco S, Voci D, Held U, Sebastian T, Bingisser R, Colucci G, Duerschmied D, Frenk A, Gerber B, Götschi A, Konstantinides SV, Mach F, Robert-Ebadi H,
Rosemann T, Simon NR, Spechbach H, Spirk D, Stortecky S, Vaisnora L, Righini M, Kucher N; OVID investigators. Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet Haematol 2022 Aug;9(8):e585-e593. doi: 10.1016/S2352-3026(22)00175-2.
Farmakis IT, Valerio L, Bikdeli B, Connors JM, Giannakoulas G, Goldhaber SZ, Hobohm L, Hunt BJ, Keller K, Spyropoulos AC, Barco S. Annual mortality related to pulmonary embolism in the US before and during the COVID-19 pandemic. J Am Coll Cardiol 2022 Aug 12:S0735-1097(22)06535-4.
Barco S*, Valerio L, Ageno W, Cohen AT, Goldhaber S, Hunt BJ, Iorio A, Jimenez D, Klok FA, Kucher N, Mahmoudpor SH, Middeldorp S, Münzel T, Tagalakis V, Wendelboe AM, Konstantinides S. Age-sex specific pulmonary embolism-related mortality in the United States and Canada, 2000-2018: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. Lancet Resp Med 2020; S2213-2600(20)30417-3.
Forgo G, Micieli E, Ageno W, Castellucci LA, Cesarman-Maus G, Ddungu H, De Paula EV, Dumantepe M, Guillermo Esposito MC, Konstantinides SV, Kucher N, McLintock C, Ní Áinle F, Spyropoulos AC, Urano T, Hunt BJ, Barco S*. An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta-analysis. J Thromb Haemost 2022 Feb;20(2):409-421.
Barco S*, Schmidtmann I, Ageno W, Anušić T, Bauersachs RM, Becattini C, Bernardi E, Beyer-Westendorf J, Bonacchini L, Brachmann J, Christ M, Czihal M, Duerschmied D, Empen K, Espinola-Klein C, Ficker JH, Fonseca C, Genth-Zotz S, Jiménez D, Harjola VP, Held M, Iogna Prat L, Lange TJ, Lankeit M, Manolis A, Meyer A, Münzel T, Mustonen P, Rauch-Kroehnert U, Ruiz-Artacho P, Schellong S, Schwaiblmair M, Stahrenberg R, Valerio L, Westerweel PE, Wild PS, Konstantinides SV; HoT-PE Investigators. Survival and Quality of Life after Early Discharge in Low-Risk Pulmonary Embolism. Eur Respir J 2020 Aug 28:2002368.
Valerio L, Fedeli U, Schievano E, Avossa F, Barco S*. Decline in Overall Pulmonary Embolism-Related Mortality and Increasing Prevalence of Cancer-Associated Events in the Veneto Region (Italy), 2008-2019. Thromb Haemost 2021 Jul 12.
Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, Kucher N, Studt JD, Sacco C, Alexia B, Sandri MT, Barco S*. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res 2020; 23;191:9-14.
Klok FA, Ageno W, Ay C, Bäck M, Barco S, Bertoletti L, Becattini C, Carlsen J, Delcroix M, van Es N, Huisman MV, Jara-Palomares L, Konstantinides S, Lang I, Meyer G, Ní Áinle F, Rosenkranz S, Pruszczyk P. Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society. Eur Heart J 2022 Jan 25;43(3):183-189. doi: 10.1093/eurheartj/ehab816.
Spirk D, Sebastian T, Barco S, Banyai M, Beer JH, Mazzolai L, Baldi T, Aujesky D, Hayoz D, Engelberger RP, Kaeslin T, Korte W, Escher R, Husmann M, Blondon M, Kucher N*. Clinical Outcomes of Incidental Venous Thromboembolism in Cancer and Non-Cancer Patients: The SWIss Venous ThromboEmbolism Registry (SWIVTER). Thromb Haemost 2020. In press.
Hobohm L, Keller K, Valerio L, Ni Ainle F, Klok FA, Münzel T, Kucher N, Lankeit M, Konstantinides SV, Barco S*. Case Fatality Rates and Use of Systemic Thrombolysis in Pregnant Women with Pulmonary Embolism. Data from the German Nationwide Inpatient Registry. ESC Heart Failure 2020; 7(5):2365-2372.
Giustozzi M, Valerio L, Agnelli G, Becattini C, Fronk EM, Klok FA, Konstantinides SV, Vedovati MC, Cohen AT, Barco S*. Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE. Eur J Int Med 2021; S0953-6205(21)00078-9.
Turatti G, Fedeli U, Valerio L, Klok FA, Cohen AT, Hunt BJ, Simioni P, Middeldorp S, Ageno W, Kucher N, Konstantinides SV, Schievano E, Barco S*. Splanchnic vein thrombosis-related mortality in the Veneto region (Italy), 2008-2019: Retrospective analysis of epidemiological data. Thromb Res 2022 Jan;209:41-46.
Spirk D, Sebastian T, Beer JH, Mazzolai L, Aujesky D, Hayoz D, Engelberger RP, Korte W, Kucher N, Barco S*. Role of age, sex, and specific provoking factors on the distal versus proximal presentation of first symptomatic deep vein thrombosis: analysis of the SWIss Venous ThromboEmbolism Registry (SWIVTER). Intern Emerg Med. 2021 Nov 3.
Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Áinle FN, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL; The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J 2019 Oct 9;54(3):1901647.