Department of Infectious Diseases and Hospital Epidemiology

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Research group Huldrych Günthard

Current projects

The research of my group includes 1) investigation of clinical and biological phenomena during acute HIV-1 infection, 2) the study of HIV-1 transmission at the biological as well as at the population level, 3) the study of transmitted as well as acquired resistance, 4) the study of the effectiveness of antiretroviral therapies and their side effects, 5) the study of the latent HIV reservoir, 6) the transmission and treatment of sexually transmitted diseases and co-infections such as hepatitis B and C, 7) virus-host interactions after HIV-1 infection (e.g. E.g., humoral and cellular immune responses).

Four major projects are briefly described below.

Funding of selected research projects

Clinical Research Focus: Viral Infectious Diseases
University of Zurich, Viral Infectious Diseases UZH

Swiss HIV Cohort Study (SHCS)
SNF: (, SHCS Group at the Clinic for Infectiology and Hospital Hygiene

HIV-1 Transmission in Switzerland: viral transmission traits, superinfection and drug resistance

The interplay of host and viral factors in the hurdle to cure HIV-1 (HIV.X)- Systems.X
Systemx.X Projects

Retrospective sequencing of plasma samples in the HIV cohort study
Yvonne Jacob Foundation

Retrospective sequencing of plasma samples as part of the HIV cohort study
Yvonne Jacob Foundation

Defining determinants of broadly neutralizing antibody evolution in viral infection to guide vaccine development
Swiss Vaccine Research Institute (funded by SERI)

Various research grants in the field of HIV-1 resistance and treatment optimization
Gilead Sciences, Janssen R&D, Pfizer



Internal collaborations

  • Prof. Dr. Roger Kouyos
  • Prof. Dr. Karin Metzner

External collaborations Switzerland

  • Prof. Niko Beerenwinkel, ETHZ-BSSE, Basel
  • Dr. Jasmina Bogojeska, IBM Rüschlikon
  • Prof. Sebastian Bonhoeffer, ETHZ, Zurich
  • Prof. Jacques Fellay, EPFL, Lausanne
  • Prof. Volker Roth, University of Basel, Basel
  • Prof. Tanja Stadler, ETHZ, BSSE, Basel
  • Prof. Alexandra Trkola, IMV, UZH, Zurich
  • Swiss HIV Cohort Study

External Collaborations Abroad

  • Prof. Joseph Wong, MD, University of California San Francisco, USA
  • Prof. Christoph Frazer, PhD, Imperial College London, UK