The research of my group includes 1) investigation of clinical and biological phenomena during acute HIV-1 infection, 2) the study of HIV-1 transmission at the biological as well as at the population level, 3) the study of transmitted as well as acquired resistance, 4) the study of the effectiveness of antiretroviral therapies and their side effects, 5) the study of the latent HIV reservoir, 6) the transmission and treatment of sexually transmitted diseases and co-infections such as hepatitis B and C, 7) virus-host interactions after HIV-1 infection (e.g. E.g., humoral and cellular immune responses).
Four major projects are briefly described below.
Clinical Research Focus: Viral Infectious Diseases
University of Zurich, Viral Infectious Diseases UZH
Swiss HIV Cohort Study (SHCS)
SNF: (http://p3.snf.ch/project-148522), SHCS Group at the Clinic for Infectiology and Hospital Hygiene
HIV-1 Transmission in Switzerland: viral transmission traits, superinfection and drug resistance
SNF: http://p3.snf.ch/project-159868
The interplay of host and viral factors in the hurdle to cure HIV-1 (HIV.X)- Systems.X
Systemx.X Projects
Retrospective sequencing of plasma samples in the HIV cohort study
Yvonne Jacob Foundation
Retrospective sequencing of plasma samples as part of the HIV cohort study
Yvonne Jacob Foundation
Defining determinants of broadly neutralizing antibody evolution in viral infection to guide vaccine development
Swiss Vaccine Research Institute (funded by SERI)
Various research grants in the field of HIV-1 resistance and treatment optimization
Gilead Sciences, Janssen R&D, Pfizer