Vascular grafts are increasingly implanted due to an increasing prevalence of atherosclerosis and diabetes, and about 1-6% of vascular procedures are complicated by infection.
Mortality attributable to prosthetic vascular graft infections (PVGI) is high. However, there are almost no data regarding best treatment options of such complicated infections. Most recommendations are based on expert opinion and not on clinical trials or cohort observational data analyses. Evaluating infectious and other complications after vascular surgery procedures are important, and additionally, such studies may offer insights for quality improvement and improved patient outcomes.
We created a prospective observational cohort database on patients with an incident prosthetic vascular graft infection (VASGRA). Additionally, we established a biobank with the collection of tissue- and blood samples of patients.
The Vascular graft cohort study (VASGRA) is an ongoing single-center research project at the University hospital Zurich dealing with adults aged 18 years or older with an implanted vascular graft and/ or prosthetic vascular graft infection (PVGI). It was established in 2013. There is a clear separation between hospital infrastructure and research budget, implementation of a quality control programs and research by nested projects. VASGRA is supported by the Swiss National Science Foundation (SNF). Our research goals are:
Evaluate histopathological features of tissue and excised vascular grafts