Treatment of alpha-1-antitrypsin deficiency (AATM)

Unfortunately, there is still no cure for AATM. However, the earlier an alpha-1-antitrypsin deficiency is diagnosed, the better the symptoms can be alleviated and the quality of life improved.

Nowadays, this disorder of the body’s metabolism can be managed well by adapting behavior and treating it with medication.

Drug treatment

The focus of AATM treatment is on relieving symptoms with bronchodilators (medication that dilates the airways) or anti-inflammatory medication. For certain patients with severe AATM, there is also the option of substitution therapy, in which the missing AAT protein is administered regularly via an infusion.

Lifestyle adjustments

Those affected can also do a lot themselves in everyday life to alleviate their symptoms:

  • Smoke-free life: Give up smoking completely and avoid passive smoking.
  • Air quality: Make sure you live in an environment with good air quality. Avoid dust, exhaust fumes and other pollutants.
  • Outdoor exercise: Integrate regular physical activity in the fresh air into your daily routine.
  • Weight management: Maintain a healthy body weight to support your overall health.
  • Diet: Make sure you eat a balanced and nutritious diet that strengthens your immune system.
  • Protection against infection: Avoid colds and get vaccinated against flu and pneumococcus.
  • Stress reduction: Minimize psychological, social and professional stress to promote your well-being.

The experts at the USZ also support you in making lifestyle adjustments to ensure the best treatment for you and your individual needs. Those affected also receive support from the patient organization“Alpha-1“.

Responsible specialist

Christian Clarenbach, Prof. Dr. med.

Senior Physician, Department of Pulmonology

Tel. +41 44 255 38 28
Specialties: Head of Interstitial and Rare Lung Diseases

For patients

As a patient, you cannot register directly for a consultation. Please get a referral from your primary care physician, specialist.

For referrering physicians

Assign your patient online, by e-mail or by post.

University Hospital Zurich
Department of Pulmonology
Raemistrasse 100
8091 Zurich

Tel. +41 44 255 22 21
Patient registration form

Responsible Department