Research Group Cosimo Bruni
Clinical research in systemic sclerosis is the focus of the group. Specifically, the group has interest in the field of prevention and improved screening of organ involvement (i.e., pulmonary fibrosis -ILD- and pulmonary arterial hypertension -PAH), exploring additional targets of medications (drug re-purposing), the application of radiomic to improve risk stratification and prognosis, as well as implementing personalized medicine, with focus on aging and gender medicine in rheumatic diseases.
Our Projects
- From ILD progression to SSc-ILD progression: a disease specific initiative (SILPRO)
- Exploring radiomics in SSc-PAH, to improve screening and risk stratification.
- ILD onset in SSc: characterization of the clinical, radiomic and biologic risk phenotype (PROFILES).
- Extra-parenchymal effects of SSc-ILD: focus on pulmonary circulation and airways
- Sex versus gender in rheumatic musculoskeletal diseases, to improve clinical practice, precision medicine and personalization of treatment (OPENNESS).
- Immunosuppressive and vasoactive medications in SSc: benefits beyond conventional targets?
Selected publications
- Bruni C, Tofani L, Fretheim H, Liem SIE, Velauthapillai A, Bjørkekjær H, Barua I, Galetti I, Garaiman A, Becker MO, Hoffmann-Vold AM, de Vries-Bouwstra J, Vonk MC, Distler JHW, Matucci-Cerinic M, Distler O. A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score. Rheumatology (Oxford). 2025 https://pubmed.ncbi.nlm.nih.gov/40811030/
- Sauer GM, Käs F, Mihai CM, Elhai M, Dobrota R, Becker MO, Muraru S, Hoffmann-Vold AM, Distler O, Bruni C. Emphysema elevates the DETECT scores: impact on pulmonary hypertension screening and diagnosis in systemic sclerosis. Rheumatology (Oxford). 2025 Dec 1;64(12):6132-6141. https://pubmed.ncbi.nlm.nih.gov/40748717/
- Käs F, Elhai M, Becker MO, Dobrota R, Mihai C, Sauer G, Tofani L, Bečvář R, Rednic S, Carreira PE, Kumánovics G, Airò P, Mueller-Ladner U, Del Galdo F, Ramazan AM, Martin M, Simeón-Aznar CP, Parvu M, Del Papa N, Hoffmann-Vold AM, Distler O, Bruni C; EUSTAR collaborators. Beyond screening for pulmonary arterial hypertension: The DETECT score is a potential promising prediction tool for all-cause mortality in systemic sclerosis: Analysis from the EUSTAR database. J Autoimmun. 2026 May;160:103555. https://pubmed.ncbi.nlm.nih.gov/42013635/
- Petelytska L, Tofani L, Velauthapillai A, Dobrota R, Becker MO, Mihai C, Muraru S, Elhai M, Jordan S, Hachulla E, Müller-Ladner U, Siegert E, Allanore Y, Riemekasten G, Bergmann C, Becvar R, Solanki K, Anic B, Szabo I, Stamenkovic B, Distler J, Carreira PE, Cuomo G, Castellví I, Balbir-Gurman A, Airò P, Litinsky I, Saketkoo LA, Bertaccini B, Vonk MC, de Vries-Bouwstra J, Hoffmann-Vold AM, Matucci-Cerinic M, Distler O, Bruni C; EUSTAR collaborators. The incidence of interstitial lung disease in patients with systemic sclerosis: rate, risk factors and prognostic implications in a EUSTAR cohort analysis (CP 133). Ann Rheum Dis. 2026 Apr;85(4):669-679. https://pubmed.ncbi.nlm.nih.gov/41549016/
- Nicholas Landini, MD PhD, Academic guest
- Florian Käs, Dr med, Academic guest
- Maria Iacovantuono, MD, Academic guest
- Liubov Petelytska, MD PhD, Academic guest