Cushing’s syndrome therapy

The treatment of Cushing's syndrome depends on the subtype. In any case, the aim of treatment is to normalize the elevated cortisol level. This is usually done by means of targeted surgery.

Treatment depends on the cause

Benign tumor of the pituitary gland

The treatment of Cushing’s disease usually consists of removing the benign tumor through the nose using an endoscopic procedure. If surgery is not possible or the symptoms do not improve after the procedure, various other procedures can be considered, which are discussed individually in a specialized board.

Tumor in the adrenal cortex

As a rule, the affected adrenal gland is surgically removed. For smaller tumors this can be done laparoscopically, for larger or malignant tumors through a skin incision.

Hormone-producing tumor elsewhere (ectopic Cushing’s syndrome)

If the hypercortisolism is caused by a tumor in another organ, an operation is usually performed to remove it.


After successful removal of the tumor, hormone replacement therapy is initially necessary in all cases until the body’s own production has recovered.

If surgery is not an option or the Cushing’s syndrome is severe, medication can help. Effective agents against hypercortisolism include metopirone, ketoconazole or mitotane.

It can take up to several months until the normalization of the cortisol level leads to a regression of all signs of Cushing’s syndrome. As a result, regular and usually longer-term follow-up checks are necessary.

Responsible senior physician

Felix Beuschlein, Prof. Dr. med.

Director of Department, Department of Endocrinology, Diabetology and Clinical Nutrition

Tel. +41 44 255 36 25
Specialties: Endocrine hypertension, Adrenal gland diseases, Endocrine tumors

For patients

As a patient, you cannot register directly for a consultation. Please get a referral from your primary care physician, specialist.

For referrering physicians

Simply assign your patient to us online.

Tel. Tel. +41 44 255 36 20
Assign online