Endovascular infections – ENVALVE Cohort Study

The focus on this clinical cohort study is based on the long-term outcome of patients with endocarditis. Furthermore, we aim to improve diagnosis and management processes. Such a register is only possible due to the important collaboration with other disciplines such as cardiology, cardiac surgery, nuclear medicine and microbiology.

The Endovascular and cardiac valve infection cohort study (ENVALVE – ENdovascular and cardiac VALVEinfection Registry: New Pathogens and Diagnostic Possibilities) is an ongoing single-center research project at the University hospital Zurich dealing with adults aged 18 years or older with an endovascular infection. It was established in 2018.

  • Epidemiology of infective endocarditis
  • Accuracy of current diagnostic tools (TTE, TEE, PET/CT)
  • Microbiology of infective endocarditis
  • Biomarkers and Biobank
  • Determine cut-off levels of blood leucocytes, ESR, CRP and procalcitonin raising suspicion of IE.


  • Dr. med. Michelle Frank, Heart center, USZ (Principle Investigator)
  • Prof. Thierry Carrel, heart center USZ
  • PD Dr. med. A. Breitenstein, Heart center, USZ
  • PD Dr. Dr. med. P. Bode, Institute of Molecular Pathology, USZ
  • PD Dr. med. R. Büchel, Clinic of Nuclear Medicine, USZ
  • PD Dr. med. A. Flammer, Heart center, USZ
  • Dr. med M. Greutmann, Heart center, USZ
  • Dr. med. Ch. Gruner, Heart center, USZ
  • Prof. Dr. med. F. Ruschitzka, Heart center, USZ
  • Prof. Dr. med. F. Tanner, Heart center, USZ
  • Prof. Dr. med. R. Zbinden, Institute of Medical Microbiology, UZH
  • Prof. Dr. med. A. Zinkernagel, Division of Infectious Diseases and Hospital Epidemiology, USZ