We have a very active program in experimental HIV medicine, in particular immunotherapy and gene engineering an HIV resistant immune system, and in gene-engineering monocytes/macrophages to fight cancer. We use all kinds of in vitro and in vivo methods. Ultimate goal is to gain insight into HIV pathogenesis, the immune network and to advance gene engineering as well as to provide pre-clinical proof of concept for future clinical trials.
The laboratory of Dr. Speck is very well embedded in the research place of Zurich and benefits from its unique scientific richness. Notably, we have very active international collaborations for the gene engineering part (Prof. Michael Pepper, University of Pretoria (SA) and Prof. Karl-Heinz Krause, University of Geneva (CH)), for studying IFNs (Prof. Gideon Schreiber, Weizmann Institute of Science, Israel) and for immunotherapy (Prof. Giuseppe Pantaleo, University of Lausanne and Prof. Renata Stripecke, University of Hannover).
The laboratory is well financed by various foundations, among others by the Swiss National Science, Swiss Vaccine Institute and the VonTobel Foundation.