The most important side effect affects women: Isotretinoin causes damage to the unborn child during pregnancy. Women may only take the medication if a medically supervised pregnancy test has been carried out before treatment and if they are using effective contraception at the same time as the treatment. Effective contraceptive methods include the pill, the IUD with simultaneous use of condoms and surgical sterilization. Condom use alone is not enough! You must continue to use contraception for at least two months after the end of treatment. Afterwards you can get pregnant again without any danger. If you become pregnant during treatment with isotretinoin, a termination of pregnancy must be considered.
For men, taking isotretinoin has no adverse effects on fertility or on a conceived child. Almost all patients who take isotretinoin experience unpleasant but harmless side effects such as dry lips, dry skin, dry nasal mucosa and dry eyes, which can be particularly annoying for contact lens wearers. These side effects can be alleviated by applying lip balm, moisturizing lotions, nasal ointment and eye drops. You also become more sensitive to sunlight and need to protect yourself accordingly.
Occasionally, increases in blood lipid levels (cholesterol etc.) and liver values occur during treatment with isotretinoin, which normalize again after the end of therapy. At the start of treatment, these values must therefore be checked every four to six weeks by taking a blood sample.
Rarer side effects include nosebleeds, slight hair loss and joint and muscle complaints. You should report these side effects to the doctor treating you.