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Research activities in Inflammatory & infectious skin diseases of the Department of Dermatology

Research groups

Hans-Dietmar Beer

Main fields of research

Keratinocytes represent the main cell type of the epidermis. This outermost layer of the skin is directly exposed to numerous types of stress, including UVB radiation. Our research tries to elucidate the mechanisms, which are responsible for the maintenance of the integrity of the epidermis under stress conditions. A protein complex, termed NLRP1 inflammasome, plays important roles in different stress-induced processes of the epidermis, including sunburn, protection against viral infection, inflammatory skin conditions and skin cancer development. Since NLRP1-dependent mechanisms are only poorly conserved in other species, such as in mice, we are establishing novel models for skin research and protocols for the stable genetic manipulation of human primary keratinocytes and skin cancer cells by state-of-the-art methods. In addition, we are interested in understanding how anti-inflammatory drugs modulate inflammasome expression and activation.

Publications

Group members

Hans-Dietmar Beer, PD PhD
Gabriele Fenini, PhD
Paulina Hennig, PhD student
Michela Di Filippo, PhD student
Tugay Karakaya, PhD student
Gilles Bilfeld, Master student

Gruppen Foto mit Mitarbeitenden des Research activities in Inflammatory & infectious skin diseases of the Department of Dermatology

Contact

Hans-Dietmar Beer, PD Dr. rer. nat.

Oberassistent, Dermatologische Klinik

Tel. +41 44 255 39 73

Philipp Bosshard

Main fields of research

Our research activities focus on skin infections and pathogen-host-interactions. This comprises research on bacterial infections (e.g. sexually transmitted infections), fungal infections and the role of the human skin microbiome in inflammatory skin diseases such as atopic dermatitis. Our main interests are epidemiological studies, to develop and improve diagnostic tools for skin infections (e.g. PCR) and to research on the human skin microbiome (e.g. next generation sequencing).

Group members

Martin Glatz, MD
Bettina Schmid, PhD student
Ksenia Mischler, MD student
Riccardo Curatolo, MD student
Moritz Klinger, MD student

Contact

Philipp Bosshard, PD Dr. sc. nat.

Oberassistent und Laborleiter FAMH, Dermatologische Klinik

Tel. +41 44 255 39 72

Barbara Meier-Schiesser

Main fields of research

Inflammatory skin diseases are frequent in number and often lead to a decreased quality of life in the affected patients. Although intense research in the field has already led to successful treatment of a number of these diseases, several questions still remain to be addressed. We aim to investigate the innate and adaptive immune pathways leading to i) severe adverse drug reactions of the skin, i.e. acute generalized exanthematous pustulosis ii) lichenoid skin diseases, iii) cancer-drug induced lichenoid skin reactions and iv) autoinflammatory syndromes. The goal of our research is to open up new relevant research avenues and to identify new therapeutic targets in difficult-to-treat diseases.

Publications

Group members

Dr. Nicola Winkelbeiner, PhD (Postdoctoral fellow)
Cadri Knoch, MD (doctoral candidate)
Jamila Hess, MD (doctoral candidate)
Patrick Poffet, MD (doctoral candidate)
Stephanie Schneider (MD master student)
Fabienne Fröhlich, MD (resident physician)
Annika Klug, research technician

Contact

Barbara Meier-Schiesser, Dr. med. Dr. sc. nat.

Oberärztin, Dermatologische Klinik
Koordinatorin Hauttumorzentrum, Comprehensive Cancer Center Zürich

Spezialgebiete: Autoimmundermatosen / Autoinflammatorische Syndrome, Arzneimittelreaktionen der Haut, Allgemeine Dermatologie
Tel. +41 44 255 11 11