Understanding the cellular and molecular bases of multiorgan fibrogenesis leading to the fatal organ remodelling in Systemic Sclerosis (SSc) is crucial for identifying potential diagnostic and therapeutic targets. Inflammation, fibrosis and vasculopathy are the hallmarks of the rare, autoimmune disease SSc. Nevertheless, despite the high unmet clinical need, so far little is known about the etiology of SSc pathogenesis and the mechanisms leading to multiorgan dysfunction in SSc patients.
We are interested in studying the role of specific stromal cell and inflammatory myeloid cell compartments in multiorgan fibrogenesis and pathological remodelling, as well in determining the origin of pathological myofibroblasts and their cellular sources in SSc. We are particularly focusing on: i) single cell level, ii) cell-to-cell interaction during the process of multiorgan inflammation and fibrogenesis, and iii) molecular mechanisms that drive this complicated signalling orchestra.