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The role of synovial fibroblasts in RA

Synovial fibroblasts are the major stromal cells in the joint synovium and play a crucial part in inflammation and joint destruction in RA.

Synovial fibroblasts from patients with RA exhibit an intrinsically activated phenotype, which is maintained under cell culture conditions and is characterised by increased expression of matrix-degrading enzymes and pro-inflammatory cytokines and chemokines. This aggressive phenotype is believed to be sustained by alterations in epigenetic modifications, such as DNA methylation and non-coding RNA. In our work, we look at different aspects of fibroblast biology to decipher how these cells are activated in RA, how they contribute to disease and how they can be therapeutically targeted.

Current projects

Group Members

Caroline Ospelt, Prof. Dr. med.

Forschungsgruppenleiterin, Klinik für Rheumatologie

Spezialgebiete: The role of synovial fibroblasts in RA
Tel. +41 43 253 31 71

Muriel Danièle Elhai, Dr. Dr. med.

Assistenzärztin , Klinik für Rheumatologie

Tel. +41 44 255 26 87

Miranda Houtman

Postdoc, Klinik für Rheumatologie

Tel. +41 43 253 31 75

Eva Camarillo Retamosa

Postdoc, Klinik für Rheumatologie

Tel. +41 43 253 31 75

Raphael Micheroli-Konuk, Dr. med.

Oberarzt , Klinik für Rheumatologie

Spezialgebiete: Psoriasisarthritis, Axiale Spondyloarthritis, Rheumatoide Arthritis, Ultraschall und US-gesteuerte synoviale Biopsien
Tel. +41 44 255 26 87

Masoume Halsadat Mirrahimi

PhD Student, Klinik für Rheumatologie

Tel. +41 43 253 31 75

Larissa Moser

MT-Assistentin, Klinik für Rheumatologie

Tel. +41 43 253 31 75

Rebecca Niederberger

MSc-Studentin, Klinik für Rheumatologie

Tel. +41 43 253 31 74