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Experimental and Molecular Pathology – Focus HPB and GI Pathology

Experimental and Molecular Pathology – Focus: Molecular Hepatobiliary and Gastrointestinal Pathology, Group Achim Weber.

The University Hospital Zurich (USZ) has a major focus on diseases of the hepato-pancreato-biliary system and gastro-intestinal tract. The Swiss Hepato-Pancreato-Biliary (HPB) center and the ENTES (European neuroendocrine tumor society) center both are centers of excellence in Zurich for diseases of the liver, biliary tract and pancreas, and gastro-entero-pancreatic neuroendocrine (GEP-NET), respectively. A professorship was implemented in 2010 to cover the need of the University of Zurich (UZH) and the USZ in research and diagnostics in the field of liver, biliary tract, pancreas, and gastrointestinal pathology.

Clinical pathology, diagnostic team and diagnostic profile

Diagnostic Profile

The team covers the whole spectrum of diagnostic pathology in the field of liver, biliary tract, pancreas, and gastrointestinal pathology. A major focus is on diagnostic molecular pathology. Besides routine diagnostic cases, these fields comprise highly specialized works and activities, such as:

  • Surgical pathology and molecular testing of cases within the Swiss Hepato-Pancreato-Biliary (HPB) center
  • Surgical pathology of neuroendocrine tumors (NET Board)
  • Molecular diagnostic of hereditary cancer syndromes including genetic testing (MEN1, MEN2, SDH, VHL)
  • Second opinion and outside consultant cases in these fields

Surgical pathology service is performed in close interaction with clinical partners within the USZ and outside. The following clinical conferences are held on a regular basis:

  1. Surgical-oncological (HPB) board (weekly)
  2. Surgical-oncological (GIT) board (weekly)
  3. Hepato-pathological conference (weekly)
  4. NET board (biweekly)
  5. Gastro-intestinal conferences (gastrointestinal clinics: USZ, Stadtspital Waid, Zürich, Spital Männedorf, GCZ – Gastro Club Zurich)

 

Research, team and research profile

Former Group Members

  • Bawohl Marion, Technician
  • Böhm Friederike, PhD, Postdoc
  • Böge Yannick, PhD, Student, PhD, Postdoc
  • Büehler Simone, Master student
  • Brack Ursula, Master Student
  • Comtesse Sarah, MD, Molecular Pathology resident
  • Frick Lukas, Master and Doctoral student
  • Heikenwälder Mathias, PhD, Professor, Academic Guest
  • Junyent Sallares Eva, MsC, intern
  • Maire Renaud, Technician
  • Maleh Mir Mohsen, PhD Student
  • Schmitt Johannes, PhD, Postdoc
  • Susanne Kreutzer, PhD Student
  • Wolf Monika, PhD, Postdoc

Research profile

The group has a focus on liver and intestinal carcinogenesis. These projects involve mouse models of diseases as well as analysis of human tissues. In addition to basic research projects, the group works on projects arising from routine diagnostic clinical and molecular pathology.

Research collaborations

The group has several intramural and external collaborations including:

  • Visceral Surgery (Pierre Alain Clavien, Rolf Graf), USZ, Zurich
  • Clinic for Gastroenterology and Hepatology (Beat Müllhaupt, Joachim Mertens, Gerhard Rogler, Michael Scharl), USZ, Zurich
  • Institute for Anesthesiology (Beatrice Beck-Schimmer), USZ, Zurich
  • Institute of Molecular Health Sciences (Sabine Werner), ETH Zurich
  • Institute of Virology (Matthias Heikenwälder, Ulrike Protzer), TU Munich, Germany
  • Institute of Pathology (Peter Schirmacher, Kai Breuhan, Thomas Longerich), University Heidelberg, Germany
  • Institute of Pathology (Erik Springer), University Mainz, Germany

Funding

Since 2010, external funding has been provided by the following organizations

  • Krebsliga Schweiz (KLS, Oncosuisse)
  • Swiss National Research Foundation (SNF)
  • Promedica Stiftung, Chur
  • Krebsliga Zürich (KLZH)
  • Julius Müller Stiftung zur Unterstützung der Krebsforschung, Zurich
  • Stiftung zur Krebsbekämpfung, Zürich
  • Theiler-Haag Stiftung, Zürich

Master and Doctoral Thesis

The group offers Master and Doctoral thesis in the field of liver and gastrointestinal pathology with both, a basic research focus or a clinically oriented. Candidates interested may contact us.

Open Positions

Candidates interested may contact us.

Contact

Achim Weber, Prof. Dr. med.

Chair Expertengruppe Molekulare Onkologie, Comprehensive Cancer Center Zürich
Stv. Institutsdirektor, Institut für Pathologie und Molekularpathologie

Tel. +41 44 255 27 81