Cancer Research Areas & Groups

CCCZ integrates and supports all cancer research activities of the UZH, USZ, Balgrist University Hospital and the University Children's Hospital Zurich.

Dedicated research areas have been established for Tumor Immunology, (Epi)Genetics & Genomics, Oncogenic Signaling and Imaging, Technology Development, and Digitalization. In these domains, scientists and physicians from over 60 research groups and clinical departments collaborate closely to expedite the translation of scientific findings into clinical practice. The overarching goal is to incorporate basic research into translational and clinical frameworks, advancing precision oncology.

CCCZ Research Groups A-Z

CCCZ Cancer Research Areas

Research findings demonstrate that the immune system can significantly impact the development and advancement of cancer. Harnessing and manipulating the immune system offer promising treatment avenues against cancer. Physicians and scientists at the CCCZ Research Area Tumor Immunology explore the dynamic interaction between tumors and the immune system. The primary goal is to develop innovative immunotherapies with minimal side effects.

Numerous traits of cancer cells, including malignant proliferation and metastatic potential, are shaped by (epi)genetic and genomic alterations. Within the CCCZ Epigenetics, Genetics, and Genomics Research Area, research teams investigate diverse facets of gene modifications in cancer, striving to formulate targeted treatment strategies.

Signal transduction pathways within and between cells are often deregulated in cancer and contribute to uncontrolled growth and metastasis. In the CCCZ Research Area Oncogenic Signaling, scientists and physician investigate the effect of cancer drugs at the molecular level. Another focus of the program is to overcome drug resistance of cancer cells.

The CCCZ Research Area for Imaging, Technology Development and Digitization pursues the goal of developing personalized diagnosis and treatment methods for cancer. Novel imaging techniques such as innovative MRI sequences and PET imaging as well as radiomics enable more precise characterization of cancer. High-throughput molecular methods like sequencing, proteomics, metabolomics and imaging are essential for molecular diagnostics and monitoring of disease progression. For the analysis of scientific and clinical data, the development of modern bioinformatics and information technologies are of central importance.